〔Abstract〕 Objective To evaluate the sleep quality of patients with chronic kidney disease(CKD) and to explore the related factors of sleep disorder in patients with CKD. Methods The basic data of hospitalization patients with CKD without renal replacement therapy were prospectively collected, and the Pittsburgh sleep quality index(PSQI) scale was used to evaluate the sleep quality of patients. Patients with a PSQI score of ≤5 were divided into the normal sleep group, and patients with a PSQI score of>5 were divided into the sleep disorder group. Logistic regression analysis was used to explore the related factors of sleep disorder in patients with CKD. Results A total of 189 patients with CKD who did not receive renal replacement therapy were included, including 114 males(60.3%) and 75 females(39.7%), aged 56.5±15.23 years. The PSQI score was 7.00(5.00, 8.00), there were 58 cases in the normal sleep group and 131 cases in the sleep disorder group, and the prevalence of sleep disorder was as high as 69.3%. As the CKD stage progresses, the prevalence of sleep disorders gradually increases. There were differences between the sleep disorder group and the normal sleep group in subjective sleep quality, sleep latency, sleep duration, habitual sleep efficiency, sleep disorder superposition problems, and daytime dysfunction(P<0.05), while there was no statistically significant difference in the scores of sleep medication use. Retirement or unemployed(OR=6.509, 95%CI:1.844-22.976) and women(OR=4.561, 95%CI: 1.241-16.767) were independent risk factors for sleep disorders, while eGFR(OR=0.960, 95%CI: 0.931-0.991) was a protective factor for sleep disorders,P<0.05. Conclusion The prevalence of sleep disorders in patients with chronic kidney disease without renal replacement therapy gradually increases with the decrease of eGFR and the increase of CKD stage, but they do not receive timely intervention with sleep improvement drugs. Clinicians need to focus on assessing sleep quality in women versus unemployed or retired patients with CKD.