〔Abstract〕 To study the effect of candesartan targeting TRAIL-DR5-mediated AMPK signaling pathway on autophagy protection of cervical cancer cells. Human cervical cancer HeLa cells were used as the study objects. The levels of TRAIL-DR5, AMPK, ATG4 A, LC3 Ⅰ, LC3 Ⅱ, Bax and Bcl-2 in HeLa cells were measured. Compared with 0 μmol/L candesartan, the apoptosis rate of HeLa cells and levels of Bax and TRAIL-DR5 increased after treatment with 15.0, 30.0 and 60.0 μmol/L candesartan(P<0.05), the levels of Bcl-2, ATG4 A, LC3Ⅱ/LC3Ⅰ and p-AMPK decreased(P<0.05), in a concentration dependent manner. Candesartan can inhibit HeLa cells proliferation and promote apoptosis, which may be related to TRAIL-DR5-mediated AMPK signaling pathway reducing the autophagy protection of HeLa cells.