〔Abstract〕 Objective To establish animal models of Echinococcosis multicocularis in 3 different regions in western of China, analyze and compare the infectivity of them. Methods Forty BALB/c mice were divided into 4 groups:normal control group(n=10), EM-1 group(Qinghai strain, n=10), EM-2 group(Xinjiang strain, n=10) and EM-3 group(Sichuan strain, n=10). The infection of abdominal cavity was established. The mice were weighed 180 days after inoculation, the infection rate was calculated, the protoscolex was isolated, the livers were fixed with 4% paraformaldehyde, HE staining was also used. The average number of protoscolex was calculated and blood was taken from the angular vein at 7 days,1 month,3 months,and 6 months,respectively,and the contents of transferase( AST),alanine transferase( ALT),alkaline phosphatase( ALP),eosinophils( EOS) and leukocytes( WBC),red blood cells( RBC),platelets( PLT) were tested. Results In this study,three mouse models of abdominal cavity infection from different regions were successfully established. There were no differences in blood routine and liver function index of BALB/c mice from 3 different regions. Among them,EM-2( Xinjiang strain) group had the most protoscolex. EM-3( Sichuan strain) had the least number of protoscolex. The EM-2 group had the highest infection rate( 77. 8%),and the EM-3 infection rate was the lowest( 62. 5%). After HE staining for the liver tissues of 3 groups of mice,vesicles of varying sizes could be seen in the liver tissues of the experimental groups under low power microscope. The Xinjiang strain infected mice could be observed serious liver cell necrosis,and the area of liver necrosis was large. Conclusion The animal models of infection in abdominal cavity of different regions have been successfully established. Pathogenicity of Echinococcosis multicocularis in different regions of mice are different. The Xinjiang strain has the most serious infectivity and the Sichuan strain has the least infectivity.