〔Abstract〕 To investigate and compare the drug resistance, virulence genes, capsular genes and ST type of Hypermucoviscous Klebsiella pneumoniae(HMKP) in Anhui regoin in Septermber 2017 and September 2018 to provide evidences for the formulation of HMKP prevention. 137 strains were isolated and identified by slime test. The minimum inhibitory concentration of antimicrobial drugs was determined by agar dilution method. Polymerase chain reaction was carried out to detect their virulence gene and serotype. Molecular typing was performed with multi-locus sequence typing. The carrying rate between the HMKP virulence gene rmpA or rmpA2 positive group and the negative group was compared. 137 strains were mainly from sputum specimens, and the isolation rate was relatively high in aged 70-79. The resistance rate of the strain to gentamicin and levofloxacin had increased. The aerobactin carrying rate was the highest in both years. K2 were the major capsular serotypes and ST65 were the major clones in 2017, K1 were the major capsular and ST23 were the major clones in 2018. In addition, the HMKP virulence gene rmpA positive group was more likely to carry rmpA2 and infect people aged 70-79 than the negative group. The HMKP virulence gene rmpA2 positive group was more likely to carry the kfu and infect people aged 70-79 than the negative group. The strains should be defined based on their phenotypes and genes for timely treatment.