〔Abstract〕 Objective To understand the clinical characteristics and laboratory data of lung space-occupying lesion, and to improve the understanding and diagnostic ability of the nature of lung space-occupying lesion. Methods 190 patients with lung-occupying space lesion who have clear pathological results by tracheoscopic biopsy or CT guided percutaneous lung biopsy were divided into benign and malignant lesion group. Malignant lesion group were further divided according to pathological types. The clinical characteristics and laboratory data of all patients were recorded in detail, then analyzed and compared between the groups. Results (1) Among 190 patients, 37(19.47%) had benign lesions while 153(80.53%) had malignant lesions. There were significant differences in smoking, lung cancer and HSP90 between benign lesion group and malignant group. 92.77% of smoking patients with high three indicators of lung cancer or HSP90 were malignant lesions. However, there was no significant difference in age, course of disease, gender, family history, CRP, abnormal glycoprotein and D-dimer between benign lesion group and malignant lesion group.(2) In the malignant lesion group, adenocarcinoma was the most, accounting for 50.98%; squamous cell carcinoma was the second, accounting for 30.07%; small cell carcinoma was 17.65%, and other types accounted for 1.31%. There were significant differences in the course of disease, gender, family history, smoking, CRP and lung cancer among different types of lung cancer, but there was no significant difference in age, abnormal glycan protein, HSP90 and D-dimer. Conclusion For the patients with smoking, and high three indicators of lung canceror high HSP90, the lung-occupying space lesion are more likely to be malignant. Combined with the clinical characteristics and laboratory data, the malignant lesion can be further diagnosed.