〔Abstract〕 Objective To investigate the microcirculation alteration in macular area and peripapillary region of myopic eyes and their relationship with axial length(AL) by optical coherence tomography angiography(OCTA). Methods A total of 66 patients(106 eyes) were selected, including 16 patients(28 eyes) in the low myopia group(control group), 23 patients(36 eyes) in the moderate myopia group and 27 patients(42 eyes) in the high myopia group. All patients were performed a complete ophthalmic examination, including spherical equivalent, slit lamp and fundus examination before OCTA inspection, then a series of parameters, including image quality, feveal density 300 μm(FD-300), A-circularity index(AI), parafoveal region superficial capillary plexus(SCP) blood flow density, deep capillary plexus(DCP) blood flow density, peripapillary blood flow density, retinal nerve fiber layer(RNFL) thickness were obtained by using OCTA and the latest version of analysis software. Results There was no significant difference in AI and SCP blood flow density among the three groups(P>0.05). There were statistically significant differences in DCP blood flow density, peripapillary microvascular density and RNFL thickness among the three groups(P<0.05). In the high myopia group and the moderate myopia group, the DCP blood flow density was lower than that of the low myopia group(allP<0.05), while the DCP blood flow density of the moderate myopia group and the high myopia group showed no statistically significant difference(P>0.05). The peripapillary microvascular density of the high myopia group was lower than that of the moderate myopia group and the low myopia group(P<0.05), while there was no statistically significant difference between the peripapillary blood flow density of the low myopia group and the moderate myopia group(P>0.05). Peripapillary blood flow density was positively correlated with RNFL thickness. The blood flow density of DCP, peripapillary vascular density, and FD-300 were all negatively correlated with the axis length. Conclusion Through analysis of OCTA, FD-300,DCP blood flow density and peripapillary microvascular density decrease accordingly with the increase of axis length. Peripapillary microvascular density and RNFL thickness decrease in high myopia.