〔Abstract〕 Objective To explore the effect of systemic lupus erythematosus(SLE) exacerbations on maternal and fetal outcomes. Methods The datas of 152 pregnant women who diagnosed with SLE were reviewed, 2 cases with labor induction were excluded because of fetal malformation. According to SLE disease activity index, the 150 patients were divided into two groups:activity group(≥5 points) with 41 cases and inactivity group(<5 points) with 109 cases. The pregnancy complications(preeclampsia, oligohydramnios and intrapartum hemorrhage) and pregnancy outcomes [days of pregnancy, birth weight, birth length, the size of the placenta, preterm delivery rate, cesarean section rate, fetal growth restriction rate(FGR), neonatal asphyxia] between the two groups were compared. Two independent samplest-test was used for the comparison of measurement datas, and chi-square test for qualitative variables. Results The incidence of preeclampsia in the activity group was significantly higher than that in the inactivity group(P<0.001). And the birth weight in the activity group was significantly lower than that in the inactivity group(P<0.01). The birth length in the activity group was smaller compared with that in the inactivity group(P<0.05). Moreover the incidence of neonatal asphyxia in the activity group was higher than that in the inactivity group(P<0.05). However, there were no statistically significant difference between oligohydramnios, bleeding volume during delivery, days of pregnancy, placental size, preterm birth, cesarean delivery, and FGR in the two groups. Conclusion SLE activity is an influential factor in the occurrence of preeclampsia. It can effect birth weight and birth length, and it is more likely to cause neonatal asphyxia. Therefore pregnant women with active SLE need to be jointly treated by rheumatologist and obstetricians. Close follow-up, timely adjustment of drugs and disease control within a stable range can greatly improve their pregnancy outcomes.