〔Abstract〕 Objective To compare the fundus fluorescein angiography(FFA) and optical coherence tomography angiography(OCTA) in diabetic retinopathy(DR) in the diagnosis of characteristics, and to analyze the consistency in the detection of DR lesions between the two methods.Methods FFA and OCTA examination was carried out in 86 diabetic patients( 166 eyes),and 26 diabetic patients( 26 eyes) who had no eye fundus changes after FFexamination were included in the experimental group,and 15 patients( 25 eyes) with age and sex matching withofundus disease were selected as the control group for OCTA examination. Two examination images were obtainedas well as a series of parameters such as blood flow density of 300μm paracentral fovea( FD-300),central foveshallow layer,deep blood flow density and surrounding area of optic disc blood flow density. Results FFA waconsistent with OCTA diagnosis DR( Kappa = 0. 514,P<0. 001). Based on FFA,foveal avascular zone changwas found in 74 eyes,macular edema was found in 59 eyes,retinal microhemangioma was found in 138 eyes,retnal neovascularization was found in 112 eyes,nonperfused areas was found in 115 eyes. Based on OCTA,the above fundus diseases were found in 81,52,125,103,101 eyes,with no statistically significant difference( P 0. 05). Compared with the control group,the density of FD-300,the blood flow density in the shallow layer,thdensity of the blood flow in the central fovea concave depression and the surrounding area of optic disc decreasedwith statistically significant difference( P<0. 05). Conclusion FFA and OCTA were generally consistent in diagnosing diabetic retinopathy,while OCTA can detect the changes of partial blood flow parameters of DR without detecting macular and optic disc lesions in FFA,providing a new index for early DM patients without changes of fundus.