〔Abstract〕 Objective To investigate the correlation between the cognitive impairment in alzheimer's disease(AD) and subdivisions of anterior cingulate cortex(ACC). Methods Forty-five patients with alzheimer's disease and forty matched heathy controls(HC) were recruited. Cognitive abilities were accessed with neuropsychological assessments. The grey matter volume(GMV) of ACC subdivisions between two groups was calculated and compared. Linear regression model was conducted for observing the relationship between the GMV of subdivisions and the cognitive impairment. Results All subdivisions of ACC of AD patients were atrophy compared to HC. The GMV of the right pregenual and subgenual ACC were crucial for the cognitive impairment, which implied the more atrophied for the subgenual ACC, the more severe for the cognitive impairment. Conclusion The pregenual and subgenual ACC played a role in the cognitive impairment in the AD progress, which might be potential targets for future therapy.