〔Abstract〕 Objectives A randomized, double-blind, controlled study was investigated the effectiveness and safety of skin care products for the purpose of repairing the skin barrier on the treatment of patients with sensitive skin. Methods According to the inclusion and exclusion criteria, 80 patients with sensitive skin were randomly selected as the sensitive group while 50 healthy people were used as the control group, and they were all treated with skin barrier repair agent and followed up at baseline and after 14 days and 28 days. The doctors made a assessment based on the differences in the patient's skin lesions, non-invasive test results and so on. Moreover, all subjects made self-assessment based on their own feelings. Statistical methods were applied to analyze the data. Results After 4 weeks of using the product continuously, patients with sensitive skin showed significant improvement in transepidermal water loss, Stratum Corneum Hydration and Skin Elasticity. The improvement rates were 92.0%, 76.0% and 65.3%, respectively. The control group had reduced epidermal oil content and enhanced skin elasticity(P<0.05). There was no improvement in the red area of visia in the two groups of subjects. The doctors evaluated the clinical symptoms of dry and flushing and the quality of life in sensitive skin patients significantly improved. And most subjects felt comfort and satisfaction. 89.3% of the subjects had high self-assessment satisfaction, and no severe skin adverse reactions were observed. Conclusion Repairing the skin barrier function has a significant clinical effect on the treatment of sensitive skin diseases, and it has a multiplier effect on the clinical treatment of sensitive skin processes.