〔Abstract〕 To investigate the expression difference of circRNA in placentas between normal pregnant women and patients with severe preeclampsia(sPE). Placental tissues were obtained from three pregnant women with sPE and three normal pregnant women. The expression of circRNA in the two groups was detected by RNA-seq technique analysis. The miRNA targets of circRNAs were predicted using miRanda software. There were 3 007 circRNAs expressed in both the experimental group and the control group. Among them, 89 circRNAs were differentially expressed, including 44 up-regulated genes and 45 down-regulated genes. Most of these differentially expressed circRNAs had binding sites for has-let-7, miR-100, miR-101, and miR-103 family members. The results indicate that these dys-regulation of circRNA in placental tissue may be involved in the pathogenesis and pathophysiology of sPE.