〔Abstract〕 Objective To observe the impact of risk factors and imaging changes of pontine infarction on short-term prognosis.Methods 111 patients with pontine infarction were divided into good prognosis group(76 cases) and poor prognosis group(35 cases) according to the mRS score at 90 days follow-up.The gender,age,smoking,complications,systolic blood pressure,diastolic blood pressure,fasting blood glucose,homocysteine(Hcy) and glycosylated hemoglobin(HbA1c) levels were compared between the two groups.Logistic regression analysis was used to analyze the factors affecting the short-term prognosis of ponstine infraction in two groups.Results There were significant differences in diabetes history(n=24,31.6%; n=18,51.4%; P=0.045),stroke history(n=18,23.7%; n=19,54.3%; P=0.001),hypertension,diabetes and stroke history(n=3,3.9%; n=9,25.7%; P =0.001),and HbA1c level(5.85 ± 1.59; 7.20 ± 2.32; P=0.005) between the good prognosis group and the poor prognosis group.Logistic multivariate regression analysis showed that history of diabetes(OR=2.518,95% CI:1.018-6.232,P=0.046),history of stroke(OR=3.822,95% CI: 1.537-9.508,P=0.004),infarct in the anterior medial area(OR=0.149,95% CI: 0.032-0.699,P=0.016) were independent risk factors for the prognosis of pons infarction.Conclusion The short-term prognosis of pontine infarction is related to the risk factors of blood vessels and the location of the infarct.The prognosis of patients with diabetes and stroke is worse.The prognosis of patients with pontine infarction whose infarct is located in the anterior medial area is better.