〔Abstract〕 Objective To investigate the improvement effect of troxerutin on myocardial lesions in type 2 diabetic cardiomyopathy model rats and its possible mechanism. Methods The mice were divided into 4 groups: control group(20 rats, normal saline), model group(20 rats, normal saline), low-dose group [20 rats, troxerutin 50 mg/(kg·d)] and high-dose group [20 rats, troxerutin 100 mg/(kg·d)]. Cardiac function was detected by cardiac color Doppler ultrasound. Plasma biochemical indicators were detected by automatic biochemical analyzer.Histopathological changes were observed by Masson,HE and TUNEL staining. Apoptosis index was detected by TUNEL staining. Immunohistochemistry and Western blot were used to detect related protein expression. Results The results of cardiac color Doppler ultrasound showed that troxerutin significantly improved cardiac function. Masson,HE and TUNEL staining showed that compared with the model group,the cardiomyocytes in the low-dose group and the high-dose group were arranged neatly,the membrane was intact,the tissue fibrosis was reduced,and the collagen fibrosis was alleviated more effectively in the high-dose group( P<0. 05). TUNEL results showed that troxerutin significantly reduced myocardial apoptosis index( P<0. 01). Immunohistochemistry and Western blot showed that troxerutin could inhibit the expression of Collagen I and Caspase-3( P<0. 05) and enhance the expression of p-AKT and p-XIAP( P<0. 05). Conclusion Triclopine has a certain improvement effect on myocardial lesions in type 2 diabetic rats,and its mechanism may be related to activation of AKT/XIAP signaling pathway,inhibition of myocardial apoptosis and myocardial fibrosis.