〔Abstract〕 To analyze the risk factors of multi-drug-resistantAcinetobacter baumannii(MDR-Ab) for intracranial infection resistance, and to provide suggestions for clinical prevention and treatment. Case control and retrospective analysis were used to study the reported cases ofAcinetobacter baumannii(Ab) infection. Patients were divided into MDR-Ab and non-MDR-Ab groups based on drug resistance. Univariate and Logistic regression analysis were used to analyze the risk factors of intracranial drug resistance in MDR-Ab with multiple drug resistance. Univariate analysis showed thathospitalization time, ICU stay, pulmonary infection, cerebrospinal fluid(CSF) leakage, CSF drainage obstruction, antibiotics use before infection Ab and hormone use after surgery were all related risk factors of MDR-Ab intracranial infection resistance(P<0.05). Logistic multivariate analysis showed thathospitalization time, ICU stay, inpatency of CSF drainage and antibiotics use before infection with Ab were all independent risk factors for MDR-Ab intracranial infection resistance(P<0.05). For patients with long hospital stay, ICU stay, unobstructed CSF drainage,and antibiotics use before Ab infection, drug resistance was easy to occur. Therefore, in the process of clinical treatment, the hospital stay should be shortened as far as possible and the patients should be moved out of ICU in time. The drainage channel should be maintained unobstructed and antibiotics should be reasonably applied.