〔Abstract〕 Objective To employ the EQ-5D-5L questionnaire to evaluate HRQOL in patients on peritoneal dialysis(PD) and investigate the related risk factors to provide suggestions for improving quality of life. Methods PD patients who were followed up regularly in the department of nephrology were recruited in this study. Demographic characteristics and laboratory data were collected. Exercise capacity was assessed by the 6-MWT. PHQ-9 was conducted to screen depression status. The EQ-5D-5L questionnaire was used to evaluate HRQOL. Multivariate linear regression analysis was used to examine the potential influencing factors of EQ-5D-5L health utility value. Results Among recruited 90 PD patients, the mean age was(49.44±11.41) years and range from 18 to 70. The highest health utility value of EQ-5D-5L was 1 point, while the lowest was-0.01 points. The mean EQ-5D-5L score was(0.92±0.15). The multivariate linear regression analyses showed that increased bilirubin level(β=-0.009,P=0.018), increased CRP level(β=-0.005,P<0.001), and increased PHQ-9 score(β=-0.008,P=0.014) were negatively correlated with the EQ-5D-5L health utility value. Increased 6-MWD(β=0.005,P=0.018) was positively correlated with the EQ-5D-5L health utility value. Conclusion The bilirubin and CRP levels, depression status, and exercise capacity are considered the main factors influencing HRQOL in PD patients.