〔Abstract〕 Objective To explore the effects of long non-coding RNA LINC00092 on the proliferation, migration and invasion of glioma. Methods Using the cancer genome atlas(TCGA) and genotype-tissue expression(GTEx) databases, this study analyzed the expression of LINC00092 in pan-carcinoma and its effect on the prognosis of glioma. In addition, LINC00092 overexpression plasmid was constructed to detect the effects of LINC00092 on proliferation, migration, invasion and apoptosis of glioma cells by cell function experiments, including CCK-8 assay, Transwell assay and flow cytometry. Finally, qRT-PCR and Western blot were used to detect the effect of overexpression of LINC00092 on the expression level of IGF2BP1. Results The analysis of public databases revealed a widespread downregulation of LINC00092 in tumors, and its association with the development of glioblastoma multiforme(GBM) and low-grade glioma(LGG).In vitroexperiments demonstrated that overexpression of LINC00092 significantly reduced the proliferation, migration and invasion of glioma cells, while promoting apoptosis. Moreover, overexpression of LINC00092 led to a decrease in the expression levels of IGF2BP1. Conclusion LINC00092 may inhibit glioma proliferation, migration and invasion by targeting IGF2BP1, and promote glioma cell apoptosis.