Comparison of clinical features and outcomes of different chorionic twins with selective intrauterine growth restriction

Acta Universitatis Medicinalis Anhui     font:big middle small

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Authors:Zhao Yujie, Zhang Ying

Keywords:selective intrauterine growth restriction;chorionicity;sIUGR;monochorionic twin;dichorionic twin

DOI:10.19405/j.cnki.issn1000-1492.2023.11.028

〔Abstract〕 Objective To delineate the similarities and differences among general characteristics and maternal-fetal outcomes in patients with selective intrauterine growth restriction(sIUGR)in monochorionic and dichorionic twin, and to compare the disparate patient types with dichorionic twin sIUGR, with an intent to furnish vital insights for clinical diagnosis and prognostic assessment. Methods Clinical data were collected from 89 patients with twin pregnancies diagnosed with sIUGR. Statistical analyses used thet-test, rank-sum test, and chi-square test. Results Pregnant women with dichorionic twins often leverage multiple assisted reproductive technologies. The maternal outcome for dichorionic twins were significantly later than that for monochorionic twins. Furthermore, the incidence of gestational diabetes mellitus was higher in dichorionic twins compared to monochorionic twins. In terms of fetal outcomes, the proportion of normal neonates with Apgar scores ≥8, body mass, and the incidence of type I sIUGR in dichorionic twin pregnancieswere significantly higher than those in monochorionic twin pregnancies. Conversely, occurrences of umbilical cord sail attachment and a smaller placental share were significantly higher in monochorionic twins. In assessing variations in sIUGR typologies among dichorionic twins, one case of intrauterine death was happened in a pregnancy with type Ⅱ/Ⅲ sIUGR typology, but none in type I. Pregnancies with type I sIUGR typology had a significantly higher proportion of large and small fetuses with Apgar scores ≥8 and better birth quality of smaller fetuses. Conclusions Compared to monochorionic twin pregnancies, there are superior maternal and fetal prognosis for dichorionic twin pregnancies with sIUGR. Clinical management should, therefore, prioritize greater attention to monochorionic twin pregnancies. In addition, this study discovers more complex outcomes in type Ⅱ/Ⅲ pregnancies among dichorionic twins, a subject area currently lacking sufficient domestic research, thereby underlining the need for meticulous monitoring and prompt intervention.