〔Abstract〕 Objective The study provided evidence for clinical prevention of colorectal cancer by analyzing the characteristics of recurrence after colorectal polypectom. Methods According to the number of polyps during the second colonoscopy, patients were divided into multiple recurrence group(≥3) and non-multiple recurrence group(<3). The characteristics and risk factors of polyp recurrence were analyzed. Results The clinical data of 370 patients who underwent two colorectal polypectomy were retrospectively analyzed. In univariate statistical analysis, polyp size(P=0.033), polyp site(P=0.002), and polyp color(P=0.032) were the risk factors for multiple polyp recurrence.In multivariate regression analysis, the number of polyps detected at the first colonoscopy(P=0.001) and the polyp site(P=0.001) were independent risk factors for multiple recurrence. Conclusion Multiple polyps on the first colonoscopy and polyps in the distal colon indicate an increased risk of multiple recurrence.