〔Abstract〕 Objective To explore the differences of serum inflammatory cytokines and tyrosine kinase with immunoglobulin and epidermal growth factor homology domains-2(Tie-2) levels between patients with first-episode schizophrenia and healthy people, and the correlation with clinical symptoms. Methods A total of 168 participants were recruited, including 86 patients with first-episode schizophrenia(patient group) and 82 healthy people(control group). Demographic data, Positive and Negative Symptom Scale(PANSS) and Brief Psychiatric Rating Scale(PANSS) were collected at baseline. Serum inflammatory cytokines and Tie-2 levels were determined by Meso Scale Discovery(MSD). Results Compared with the control group, the levels of serum interleukin(IL)-1β and IL-4 in the patient group increased(P<0.05), while the level of Tie-2 decreased(P<0.05). IL-1β level in the patient group was positively correlated with the total score of BPRS, the score of BPRS hostility factor and the score of PANSS positive scale factor(P<0.05). The positive score of PANSS and the total score of BPRS in the patient group had a positive effect on IL-1β level(P<0.05).PANSS negative scale factor score, general psychopathological scale factor score and total score of PANSS in patient group also had positive effects on Tie-2 level(P<0.05). IL-1β level in the patient group could effectively predict the severity of clinical symptoms in patients with first-episode schizophrenia at the critical level of 1.181 pg/L, with a specificity of 0.850 and a sensitivity of 0.972. Tie-2 level in the patient group can effectively predict the severity of clinical symptoms in patients with first-episode schizophrenia at the critical level of 2 127.076 pg/L, with specificity of 0.675 and sensitivity of 0.639. The AUC of IL-1β and Tie-2 were 0.836 1 and 0.646 2, respectively. Conclusion The levels of IL-1β, IL-4 and Tie-2 in patients with first-episode schizophrenia are different from those in healthy people. IL-1β levels in patients with first-episode schizophrenia are correlated with part of clinical symptoms. IL-1β and Tie-2 levels in the patient group may be influencing factors with high sensitivity and specificity in predicting the severity of clinical symptoms in patients with first-episode schizophrenia.