〔Abstract〕 Objective To investigate the feasibility and safety of transumbilical single-port laparoscopic total hysterectomy with a self-made single-port laparoscopic platform for uterine fibroids. Methods 114 patients with uterine fibroids who needed total hysterectomy were divided into 3 groups: Microchannel transumbilical single-port laparoscopy group(group Micro-channel,n=38), standard access transumbilical single-port laparoscopy group(group Single-port,n=25) and traditional laparoscopy group(group Traditional,n=51), in which self-made single-port laparoscopic access platform was used in group Micro-channel and group Single-port. The operation time, intraoperative blood loss, preoperative and postoperative hemoglobin value changes, postoperative VAS pain score, incision cosmetic score, postoperative complications, postoperative gastrointestinal recovery time, treatment costs and hospital stay were compared among the three groups. Results Compared with the other two groups, Microchannel transumbilical single-port laparoscopy group had less intraoperative blood loss, shorter hospital stay, faster postoperative recovery, lower postoperative VAS score and higher postoperative cosmetic score, and the differences were statistically significant(P<0.05). Transumbilical single-port laparoscopic surgery had shorter discharge time, lower pain scores, and better cosmetic scores than traditional laparoscopic surgery, and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of postoperative complications, the rate of postoperative analgesic use and the change of postoperative hemoglobin among the three groups(P>0.05). Conclusion Microchannel transumbilical single-port laparoscopic surgery is safe and effective in the treatment of uterine fibroids, and can improve the therapeutic effect of patients. The self-made single-port laparoscopic platform is safe and effective, and can reduce the cost of treatment for patients.