〔Abstract〕 Objective To analyze the association between multiple loci of genes and the risk of early-onset preeclampsia(EOPE) with pregnancy induced hypertension. Methods Among 382 EOPE patients who had lived in Yanbian area for more than 10 years, 192 patients were randomly selected as case group.At the same time, 192 cases of natural delivery in the hospital were randomly selected as the control group.PCR-RFLP method was used to determine the specific genotype and allele distribution information, and non-conditional Logistic method was used to obtain odds ratio(OR) and 95% confidence interval(CI) to confirm the risk of various genotypes. Results There were two alleles of T and C at theGRB2rs8082005 locus, TC, TT, and CC genotypes. There were two alleles of T and C at theRXRArs3849222 locus, TC, TT, and CC genotypes. Through unconditional logistic regression analysis, in theGRB2rs8082005 locus, compared with the TT genotype, the CC genotype was more susceptible to EOPE(OR=3.155, 95%CI=1.513-6.579,P=0.002). In the explicit model, compared to patients with TT+TC genotype, patients with CC genotype increased the risk of EOPE(OR=3.000, 95%CI=1.495-6.022,P=0.002). In theRXRArs3849222 locus, compared with the CC genotype, the TT genotype was more susceptible to EOPE(OR=2.031, 95%CI=1.077-3.820,P=0.028). In the invisible model, compared to patients with CC+CT genotype, patients with TT genotype had an increased risk of EOPE(OR=2.549, 95%CI=1.421-4.573,P=0.002). Conclusion There is a significant correlation between single nucleotide polymorphism(SNP) at theGRB2rs8082005 andRXRArs3849222 loci and the risk of EOPE in pregnant women with gestational hypertension in Yanbian area.