〔Abstract〕 Objective To investigate the effect of QDPR on renal interstitial fibrosis and Beclin1 expression of unilateral ureteral obstruction(UUO) rat model. Methods The UUO model was constructed by unilateral ureteral ligation.The fibrosis progression, QDPR and Beclin1 expression of UUO model were evaluated by Masson, COL Ⅰ staining and Western blot techniques.UUO model which was over expression QDPR and its control were constructed by retrograde ureteral infusion of corresponding lentivirus.Infection efficiency and QDPR expression level were further evaluated.The QDPR overexpression on fibrosis progression, and Beclin1 was further analyzed. Results Compared with the sham operation group, the collagen fibers level in the UUO model group significantly increased(P<0.05),the QDPR expression level was significantly reduced(P<0.05),and the Beclin1 significantly increased(P<0.05).Retrograde injection of lentivirus through the ureter could successfully infect the kidney and increase the expression level of QDPR in the kidney.The overexpression of QDPR in kidney could significantly decrease collagen fibers(P<0.05) and Beclin1(P<0.05) expression. Conclusion Overexpression of QDPR inhibits the expression level of Beclin1 and progression of fibrosis, suggesting that overexpression of QDPR may relieve renal interstitial fibrosis by inhibiting Beclin1expression.