〔Abstract〕 Objective To compare the diagnostic efficacy of three screening methods, including the epidemiological survey and the new gastric cancer scoring system proposed in the Expert Consensus Opinion on Early Gastric Cancer Screening Process in China(Shanghai, 2017), and the Kyoto classification score for screening gastric in early gastric cancer diagnosis. Methods Patients who underwent endoscopic submucosal dissection and were pathologically confirmed were included in the gastric cancer group, patients with non-gastric cancer in the same period were consecutively included in the control group. Questionnaires and serological tests were performed in all enrolled patients, and the endoscopic presentations was recorded according to the classification of Kyoto gastritis during gastroscopy. The risk stratification and the detection rates of gastric cancer were estimated by different screening methods, and the receiver operating characteristic curve(ROC curve) of subjects diagnosed with each screening method alone and in combination were plotted to compare the area under the ROC curve(AUC) and the diagnostic efficacy. Results Among all participants, 84 were patients with gastric cancer and 120 were normal people without gastric cancer. The Kyoto risk score had the highest diagnostic value(AUC=0.79) among the others, and its sensitivity and specificity were 72.6% and 79.1%, respectively, but the combined diagnosis of different methods did not significantly improve the diagnostic efficacy. The Kyoto risk score had a more discriminative value in the medium to high-risk group delineated by the new scoring system. Conclusion The Kyoto risk score has high clinical value in the diagnosis of early gastric cancer and can be used in conjunction with the new scoring system for early gastric cancer risk assessment.