Preparation and performance of an adhesive hemostatic dual-network hydrogel

Acta Universitatis Medicinalis Anhui 2023 02 v.58 243-247     font:big middle small

Found programs:

Authors:Ding Yufan; Su Rui; Pan Zhao; Wen Huiqin

Keywords:methacryloxyethyltrimethyl ammonium chloride;acrylamide;gelatin;dual-network hydrogel;synergistic physical hemostasis and chemical hemostasis

DOI:10.19405/j.cnki.issn1000-1492.2023.02.012

〔Abstract〕 Objective To prepare an adhesive hemostatic hydrogel and examine its hemostatic performance and biocompatibility. Methods The precursor components were homogenously dissolved and photo-crosslinked in order to form dual-network hydrogel. The electron microscopy morphology was then analyzed; mechanical properties were tested;in vitrohemostatic performances were investigated by whole blood clotting test and simulation trial of cutaneous bleeding. Further, the hemocompatibility was evaluated. Results A characteristic porous network structure was presented through microscopy observation of the sample. The tensile strength of hydrogel reached 46 kPa, and strong adhesion was achieved between the hydrogel andex vivobiological tissues. Hydrogel had significant effect on wound closure and clotting time could be shortened to 1 minute. Conclusion The hydrogel was capable of accelerating coagulation due to its ability to accumulate platelets and red cells after blood contact. The dual-network hydrogel with good hemocompatibility enabled excellent hemostatic performance by the synergistic effects of the chemical activation mechanism and physical hemostatic effect.