〔Abstract〕 Objective To investigate the 90 day prognosis of acute ischemic stroke patients treated with mechanical thrombectomy in the real world and analyze the related factors of prognosis. Methods A total of 1 033 acute ischemic stroke patients treated with mechanical thrombectomy in tertiary hospitals of Anhui province were retrospectively investigated. The 90 day modified Rankin Scale(mRS) score was evaluated by follow-up telephone, 0～2 points were good prognosis and 3～6 points were poor prognosis. Results A total of 770 patients were followed up, with an average age of(67.7±11.8) years. The good prognosis rate was 32.1% and the mortality rate was 31.8%. With the increase of age, the good prognosis rate showed a downward trend while the mortality rate showed an upward trend. The best cut-off value for age prediction of 90-day mortality was 69 years old. There was no gender difference in the good prognosis rate between women(70.6±10.6)years and men(65.6±12.2)years, but females experienced a higher mortality than males(37.1%vs27.9%) before adjusting for age. Comparison was made among provincial, municipal and county hospitals, only the good prognosis rate of provincial hospitals was significantly higher than that of county hospitals(37.2%vs15.6%). In the grouping of annual number of endovascular treatment cases, the good prognosis rate of only ≥40 cases group was significantly higher. There was no significant difference in mortality among the groups. Conclusion At present, the good prognosis is low and the mortality is high for the whole acute ischemic stroke patients treated with mechanical thrombectomy. Age was positively correlated with poor prognosis and mortality. The higher mortality rate in women than in men is due to the higher average age of onset in women. The good prognosis rate of provincial hospitals and hospitals with annual number of endovascular treatment ≥40 cases is higher than that of other hospitals.