〔Abstract〕 Objective To explore the factors associated with the transplant outcomes after the treatment of preimplantation genetic testing(PGT) for infertile patients. Methods A retrospective analysis of data of frozen-thawed embryo transfers in PGT for structural rearrangements/PGT for monogenic(PGT-SR/PGT-M) cycles was performed. According to the transplant outcomes, it was divided into the pregnancy group(74 cases) and the non-pregnancy group(74 cases). The factors including male age, female age, duration of infertility, number of abortion, female BMI, follicle-stimulating hormone(FSH), luteinizing hormone(LH), estradiol(E2), progesterone(P), blood glucose, insulin, albumin, total cholesterol, triglycerides, high-density lipoprotein(HDL), parents′ causes of infertility, type of chromosomal abnormality, number of retrieved oocyte, number of meiosis II(MII), number of fertilization, number of two pronuclei(2PN), endometrial thickness on embryo transfer day, endometrial preparation, day of embryo development, presence of a top quality embryo(TQE) or not were analyzed by the Mann-Whitney U test and Pearson′s chi-square test. The probability of transplant outcomes in correlation with the relevant parameters analyzed was measured with multivariate logistic regression analysis. Results Univariate analysis indicated that E2, insulin, total cholesterol, triglycerides and endometrial preparation were significantly associated with transplant outcomes in PGT-SR, PGT-M cycles(P<0.05). Multiple logistic regression analysis revealed that lower levels of insulin(OR=0.14, 95% CI=0.03-0.27) and triglycerides(OR=1.38, 95% CI=0.14-2.78) in women were beneficial to transplant outcomes in PGT cycles. For endometrial preparation, compared with natural cycles, hormone replacement therapy(HRT) cycles(OR=3.52, 95% CI=2.54-4.65) were another factor to improve transplant outcomes. Conclusion There is a correlation between the levels of insulin and triglycerides, endometrial preparation and transplant outcomes in PGT cycles. In detail, lower levels of insulin and triglycerides, and the HRT cycle can lead to a better transplant outcome.