〔Abstract〕 Objective To investigate the relationship between the single nucleotide polymorphism of PPARG rs2290449 and the efficacy of combination therapy in sepsis patients with MODS. Methods 382 cases of sepsis with MODS were selected and divided into the effective group and the ineffective group, and a case-control study was conducted. PCR-RFLP and Sequenom MassARRAY were used to detect the genotype and allele frequencies of the loci. Unconditional Logistic regression was used to calculate odds ratio(OR) and 95% confidence interval(CI) to evaluate the efficacy of combination therapy for sepsis with MODS in patients with different genotypes. Results There were G and A alleles in PPARG rs2290449 locus, GG、GA and AA genotype. Non-conditional Logistic regression analysis showed that compared with the GG genotype group, the GA genotype group had a significant correlation with the efficacy of combination therapy for sepsis with MODS(OR=0.449,95%CI=0.280-0.722,P=0.001). In the dominant model, there was a significant correlation between the GA+AA genotype and the efficacy of combination therapy compared with the GG genotype(OR=2.104,95%CI=1.332-3.321,P=0.001).After adjusting for confounding factors, unconditional Logistic regression analysis showed that compared with the GG genotype, the GA+AA genotype was significantly correlated with the efficacy of combination therapy in sepsis patients with MODS(OR=2.307,95%CI=1.438-3.701,P=0.001). Stratified analysis showed that compared with the population carrying GG genotype, the population carrying GA+AA genotype was significantly correlated with the efficacy of combination therapy in sepsis with MODS in the stratified analysis of age, gender and ethnicity. Conclusion PPARG rs2290449 single nucleotide polymorphism is significantly correlated with the efficacy of combination therapy in sepsis patients with MODS in Yanbian area.