〔Abstract〕 Objective To compare the effect of BoneCeramic and Bio-OSS on osteogenic after PAOO and bone marrow stromal osteogenic differentiation in rats. Methods 36 8-week-old SD rats were enrolled and divided into 3 groups: corticotomy group(CO group);corticotomy+Bio-Oss implantation group(BO group);corticotomy+BoneCeramic implantation group(BC group).Immediately, a standard orthodontic spring(50 N/kg) was activated to pull the right upper first molars toward midrange movement.At 28,60 days after activation, 6 rats were randomly selected from each group and sacrificed.The mesial movement distance, palatal alveolar bone height loss(ABHL) and bone volume fraction(BVF) of the first molars were measured by micro-CT.The effects of the two materials on the osteogenic differentiation of rat bone marrow mesenchymal stem cells(BMSCs) were investigatedin vitro. Results There was no difference in tooth movement between the three groups; The ABHL value of the control group was higher than that of the experimental group at 28 and 60 days, and the BVF value was lower than that of the two groups.Meanwhile, the ABHL value of the BO group was higher than that of the BC group at 60 days, and the BVF value was lower than that of the BC group.CCK-8 showed that the two materials did not inhibit the growth of BMSCs.SEM showed that BMSCs were more distributed on the surface of BoneCeramic material.Quantitative ALP detection showed that BMSCs exhibited higher ALP activity on the surface of BoneCaremic material, and mRNA expressions of RUNX-2,OPN and OCN were higher. Conclusion BoneCeramic is more beneficial to osteogenesis after PAOO and osteogenic differentiation of BMSCs in SD rats.