〔Abstract〕 Objective To investigate the factors affecting the outcome of high-risk human papillomavirus( HRHPV) infection in patients with normal cervix examined by colposcopy in Hefei area and the relationship between persistent HR-HPV infection and cervical cytology. Methods Data of colposcopy patients were collected from 478HR-HPV infected patients with normal cervix through colposcopy. Their age,number of sexual partners,contraceptive methods and other relevant basic information were recorded. Vaginal interferon use,HR-HPV infection at year1 and year 2,and cervical liquid-based cytology test( LCT) results were tracked,univariate and multivariate analyses were performed based on basic information,and ROC curves were plotted. Results The HR-HPV clearance rate at 1 year was 59. 41%,and the clearance rate at 2 years was 66. 75%. The other 12 types of infection( 31,33,35,39,45,51,52,56,58,59,66,68) were more common than the 16 and 18 types. Univariate and multivariate analyses showed that age>50 years,number of sexual partners ≥2,and history of cervical conectomy increased the risk of persistent HR-HPV infection( χage2= 21. 676,P<0. 001; χnumber2of sexual partners= 8. 262,P =0. 004; χ(history of cervical conectomy)2= 11. 267,P = 0. 001). The risk of HR-HPV infection was significantly lower when condom or vaginal interferon was used( χ(condom use)2= 10. 885,P = 0. 001; χ(interferon use)2= 4. 099,P = 0. 043). The area under the ROC curve( AUC) of combined diagnosis of HR-HPV persistent infection was higher than that of single diagnosis,and the AUC of combined diagnosis was 0. 737. Persistent HR-HPV infection was an independent risk factor for abnormal LCT,and the AUC predicted by the model was 0. 755. No cancer was found in patients with persistent HR-HPV infection for 2 years,and the proportion of abnormal LCT was higher than that in patients with negative HR-HPV. The difference was statistically significant( χ2= 39. 64,P<0. 001). Conclusion The combined ROC model constructed for patients>50 years old,with multiple sexual partners,history of cervical surgery,no vaginal interferon use,and no condom use has certain value in predicting persistent HR-HPV infection,and persistent HR-HPV infection has predictive value in predicting LCT abnormalities.