〔Abstract〕 Asthma is a well-characterized heterogeneous disease marked by airway remodeling and chronic air- way inflammation . Clinically , the treatment of asthma primarily relies on hormonal drugs . However , the long-term use of these medications can lead to significant side effects . Mitophagy is a biological process that selectively trans- ports damaged mitochondria to lysosomes for degradation . Recent research has revealed the crosstalk between mito- phagy and asthma. Accordingly , taking mitophagy as an entry point , summarizing the key molecular mechanisms and regulators of mitophagy in asthma will facilitate the development of novel intervention targets and strategies for asthmatic treatment.