〔Abstract〕 Breast cancer is the most common malignancy among women worldwide , and its recurrence , metastasis , and drug resistance remain significant challenges in systemic treatment. Metabolic alterations are a hallmark of cancer , with breast cancer cells reprogramming glucose metabolism , lipid metabolism , and amino acid metabolism to adapt their nutrient acquisition pathways . This metabolic reprogramming enables cancer cells to meet the energy demands for rapid proliferation and adaption to the microenvironment of metastatic sites , which is closely associated with resistance to chemotherapy , targeted therapies , and immunotherapies . This review summarizes the features of metabolic remodeling in breast cancer , the mechanisms by which metabolic adaptation contributes to treatment re- sistance , and emerging individualized strategies targeting metabolic vulnerabilities . Particular focus is placed on en- ergy metabolism , cholesterol homeostasis , and glutamine utilization in relation to tumor invasion , metastasis , and drug resistance . A better understanding of metabolic adaptation and accurate monitoring of metabolic dynamics may offer new insights into metabolic therapies and improve clinical outcomes .