〔Abstract〕 Opioids are commonly used drugs in the clinic , mainly targeting different subtypes of opioid receptors distributed in central and peripheral neurons . They are the preferred drugs for treating acute pain or cancer pain . Delta opioid receptor (DOR) agonists are opiate drugs that target the delta receptor. In recent years , they have re- ceived widespread attention due to their ability to improve ischemia/reperfusion injury in multiple organs such as the heart , brain , and liver , as well as their potential for treating mental and neurological disorders . This review summarizes the mechanism research of DOR agonists in treating a variety of diseases , prospects their clinical appli- cation prospects , and finds that DOR agonists may exert anti-ischemia/reperfusion injury effects on organs by re- ducing apoptosis and mitochondrial damage , and activating various signaling pathways; they also exhibit anti-in- flammatory , antidepressant , and therapeutic effects on neurodegenerative diseases , providing a new perspective for the application of DOR agonists in treating related diseases .