〔Abstract〕 To investigate the characteristics of temporal and spatial distribution of tuberculosis epidem- ics in Shache County , Kashgar Region , Xinjiang. Methods Information on the incidence of tuberculosis in Sacha County from 2019—2021 was collected and spatiotemporally analyzed by applying the circular distribution method , local spatial autocorrelation analysis , hot and cold spot analysis , directional distribution and spatial center of gravity methods . Results The total number of tuberculosis cases in Shache County in 2019—2021 was 8 , 345 , of which 52. 03% were male and 47. 97% were female , and the patients were predominantly 60 - 75 years old . The number of reported incidences of TB in Tagarqi Township , Shache Township , and Chajek Township ranked among the top three in the county . Spring and summer were the disease-prone seasons for TB , and mid-March to mid-July was the period of high disease incidence . Misha Township and Ishkuli Township are the “high and high ”gathering areas , while the “low and low ”gathering areas are mainly concentrated in Khoshrav Township and Karasu Township . The hotspots of TB incidence in Shache County were Tagarqi Township , Misha Township , and Ishkuli Township . During the study period , the center of gravity of TB incidence in shache county of kashgar area gradually shifted from the southwest to the northeast. Conclusion In Shache County , there is a certain degree of aggregation of tuberculosis outbreaks , with more men than women reporting illnesses , a larger proportion of older people , and a strong seasonal incidence of the disease , with Mixia Township and Ishikuli Township being the key areas of incidence . Relevant departments should continue to strengthen the disease surveillance of key populations and regions during the high incidence of tuberculosis , and take appropriate intervention measures to reduce the risk of tuberculosis transmis- sion .