〔Abstract〕 Liver metastasis is one of the most common complications of advanced lung cancer and an important fac- tor influencing patient prognosis and survival . Currently , there are limited effective treatment options for lung canc- er patients with liver metastasis , leading to short survival and poor prognosis . In-depth studies of the related molec- ular mechanisms are crucial for advancing clinical translation and optimizing therapeutic strategies . In recent years , more and more studies of the mechanisms of liver metastasis in lung cancer have performed , particularly in areas such as the roles of different proteins , cell-cell interactions , and changes in the tumor microenvironment. This re- view summarizes the current understanding of the basic process of lung cancer liver metastasis , regulatory proteins , signaling pathways , tumor microenvironment changes , and clinical treatment progress . E merging evidence high- lights the critical involvement of TGF-β/smad signaling pathway and integrin family proteins in promoting lung cancer liver metastasis . In the tumor microenvironment , various cell types including mononuclear phagocytes , fi- broblasts , and hepatocytes contribute to this metastatic process . Clinically , the combination of immunotherapy with chemotherapy , radiotherapy , and antiangiogenic therapy has shown potential to improve treatment outcomes . Fur- thermore , targeted therapy against specific pathways , proteins , and cells within the tumor microenvironment , as well as the integration of multiple treatment modalities , holds promise for becoming effective strategies in the future clinical management of lung cancer liver metastasis .