〔Abstract〕 Objective To explore the expression of collagen type 1 alpha 2 (COL1A2) in cervical cancer and its correlation with immune infiltration. Methods Bioinformatics techniques were used to analyze the expression of COL1A2 in cervical cancer. Western blot and RT-qPCR were used to detect the expression of COL1A2 in cervical cancer tissues and cell lines. The correlation between the expression of COL1A2 and tumor immune cell infiltration was analyzed by tumor immune estimation resource (TIMER2.0). Gene set enrichment analysis (GSEA) was used to analyze the possible mechanism of COL1A2 in cervical cancer. Jaspar database was used to predict the transcription factors of COL1A2. Western blot and RT-qPCR were used to detect the expression of transcription factors in cervical cancer tissues and cell lines. Results The expression of COL1A2 was down-regulated in cervical cancer ( P < 0.05). The expression of COL1A2 was positively correlated with the levels of macrophages and myeloid dendritic cells ( P < 0.01). The proportions of 22 types of immune cells were different in different cervical cancer patients. In addition, compared with the high expression group of COL1A2, the proportion of M0 macrophages, M2 macrophages and resting memory CD4 + T cells increased in the low expression group of COL1A2, while the proportion of CD8 + T cells, activated memory CD4 + T cells, follicular helper T cells, activated NK cells and activated myeloid dendritic cells decreased ( P < 0.05). GSEA analysis showed that COL1A2 was related to immune-related signaling pathways, including Notch signaling pathway, interleukin-6/janus kinase/signal transducer and activator of transcription 3 (IL6/JAK/STAT3), Wnt/β-catenin signaling pathway, etc. ( P < 0.01). Jaspar database predicted that the transcription factor of COL1A2 was paired box protein 5 (PAX5), and the expression of PAX5 decreased in cervical cancer ( P < 0.05). Conclusion COL1A2 is expected to become a potential diagnostic biomarker and immunotherapy target for cervical cancer.