〔Abstract〕 Objective To prepare a kind of baicalin-loaded gelatin/chitosan coaxial electrospinning membrane to solve the problem of diabetic inflammatory wound healing. Methods The membrane was prepared by coaxial electrospinning technology, and its physicochemical and biological properties were evaluated by tensile test, in vitro simulation and cell co-culture. Results Baicalin combined with gelatin/chitosan membrane was prepared, the fiber diameter was about 100 nm, the tensile strength after crosslinking was 13.38 MPa, the release of baicalin could reach 1 week, and the inflammatory environment was simulated in vitro. Baicalin had anti-inflammatory effect within a certain concentration range, and the survival rate of 5-day cells was nearly 100%. Conclusion The prepared baicalin combined with gelatin/chitosan membrane has good mechanical strength and excellent biocompatibility, providing a material basis for solving the problem of difficult wound healing.