Found programs: National Natural Science Foundation of China (No. U24A20764); Clinical Medical Research Translational Project of Anhui Province (No. 202204295107020002); Natural Science Research Project of Anhui Educational Committee (No. 2022AH010072)
Authors：Yao Xiang1,2,3 ，Xu Wenjuan1,2,3 ，Wang Jianye1,2,3 ，Gao Qun4 ，Zhao Gang5 ，Zhou Ping1,2,3
Keywords：thyroid cancer; assisted reproduction; pregnancy outcomes; fertility needs; women of childbearing age; fertility assistance outcome
DOI：专辑：医药卫生科技
〔Abstract〕 To evaluate the pregnancy outcomes of assisted reproductive technology (ART) in women with a history of thyroid cancer who retained fertility intentions after completing cancer treatment. Methods A retrospective analysis was performed on 61 patients with a history of thyroid cancer who underwent in vitro fertilization/intracytoplasmic sperm microinjection and embryo transfer (IVF/ICSI-ET). These patients were included as the case group. A total of 122 non-cancer patients who received ART during the same period were selected as the control group using 1:2 matching based on age and oocyte retrieval time. Baseline characteristics, outcomes of the first ART cycle, and cumulative pregnancy outcomes were compared between the two groups. Results There was no significant difference in the basic data, the total amount of gonadotropin (Gn) and the days of use between the case group and the control group (P＞0.05). However, the case group had significantly fewer retrieved oocytes, mature oocytes (MII), lower fertilization and cleavage rates, and fewer transferable and high-quality embryos, as well as fewer embryos transferred during the first cycle (P < 0.05). However, there was no significant difference in the rate of first embryo implantation and first clinical pregnancy between the two groups (P > 0.05). In the analysis of cumulative outcomes, the two groups did not show statistically significant differences in the cumulative pregnancy rate, clinical pregnancy rate per transfer cycle, number of egg retrieval cycles required to achieve each live birth, number of transfer cycles, and number of embryos used (P > 0.05). However, the cumulative live birth rate was significantly lower in the case group compared to the control group (P = 0.005). Conclusion After treatment for thyroid cancer, when ART is used to help pregnant women, the pregnancy outcome is comparable to that of women without tumors. Individualized reproductive management and timely fertility preservation strategies are recommended to optimize reproductive outcomes in this population.