Found programs: National Natural Science Foundation of China (No. 82171619); Research Project of Anhui Provincial Institute of Translational Medicine (No. v2023zhyx-C48)
Authors：Wang Ying1,2,3 ，Xu Xuan1,2,3 ，Zhang Longyu1,2,3 ，Wu Rong1,2,3 ，Hu Jingjing1,2,3 ，Yang Wenjuan1,2,3 ，Wu Xiao1,2,3 ，Wei Zhaolian1,2,3
Keywords：intrauterine adhesions; transcervical resection of adhesions; platelet-to-lymphocyte ratio; systemic immune-inflammation index; neutrophil-to-lymphocyte ratio
DOI：专辑：医药卫生科技
〔Abstract〕 To investigate the correlation between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and the severity of intrauterine adhesions (IUA) . Methods The retrospective study included 380 patients who underwent transcervical resection of adhesions (TCRA) from December 2019 to March 2025. Based on the American Fertility Society (AFS) classification, patients were divided into mild (n=61), moderate (n=225), and severe (n=94) groups. NLR, PLR, and SII were calculated from preoperative blood tests. Statistical analyses included Kruskal-Wallis test and ordinal Logistic regression. Results NLR, PLR, and SII were significantly higher in the severe IUA group compared to the mild group (P<0.05), with SII showing the strongest predictive ability ( OR=1.004, P=0.001) . The number of intrauterine procedures was an independent risk factor (OR=1.27/level, P=0.016) . The predictive model [logit(P)=-0.676+0.241×operation times+0.004×SII] effectively identified severe IUA cases. Conclusion Inflammatory markers (particularly SII) are correlated with IUA severity and may serve as non-invasive tools for clinical assessment.