〔Abstract〕 To investigate the diagnostic value of coagulation function indicators and proteinuria in preeclampsia and its severity assessment. Methods A total of 239 pregnant women who visited our hospital from January 2022 to December 2023 were selected as research subjects. They were divided into healthy control group (n=50), non-gestational hypertension group (n=39), and gestational hypertension group (n=150) based on clinical diagnosis. The gestational hypertension group was further subdivided into three subgroups: simple hypertension group (n=50), mild preeclampsia group (n=50), and severe preeclampsia group (n=50). The study compared differences in plasma protein S (PS), plasma protein C (PC), fibrin degradation products (FDP), fibrin monomer (FM), and proteinuria levels among different groups. The correlation between proteinuria and coagulation function indicators in patients with gestational hypertension was analyzed, and ROC curves were used to analyze the diagnostic efficacy of coagulation indicators and proteinuria for gestational hypertension and different stages of preeclampsia. Results The gestational hypertension group showed lower PS and PC values compared to the non- gestational hypertension group and healthy control group, while FDP, FM values, and proteinuria levels were higher than those in the non-gestational hypertension group and healthy control group (P<0.05). Significant differences in coagulation indicators and proteinuria levels were observed among pregnant women with different degrees of gestational hypertension (P<0.05). The AUC values for diagnosing gestational hypertension using PS, PC, FDP, FM, and proteinuria were 0.927, 0.957, 0.967, 0.947, and 0.932 respectively (P<0.000 1). For diagnosing simple hypertension and mild preeclampsia, the AUC values were 0.875, 0.777, 0.830, 0.678, and 0.935 respectively (P<0.000 1). For diagnosing mild and severe preeclampsia, the AUC values were 0.900, 0.776, 0.779, 0.806, and 0.847 respectively (P<0.000 1). Conclusion Coagulation function indicators and proteinuria show significant differences between healthy pregnant women and those with gestational hypertension. PS, PC, FDP, FM, and proteinuria levels vary among pregnant women with different stages of preeclampsia. The aforementioned indicators exhibit certain diagnostic efficacy for gestational hypertension and preeclampsia.