〔Abstract〕 Objective To investigate the effects of cognitive behavioral therapy(CBT) combined with SSRI on heart rate variability and vascular endothelial cell function in patients with coronary heart disease(CHD) complicated with anxiety disorder. Methods Ninety patients with CHD combined with anxiety disorder were randomly divided into observation group(CBT combined with SSRI treatment) and control group(SSRI treatment). The changes of 17 items of Hamilton Depression Scale(HAMD-17) score, Hamilton Anxiety Scale(HAMA) score, heart rate variability and vascular endothelial cell function were compared between the two groups before and after treatment. Results After treatment, HAMD-17 and HAMA in both groups were lower than those before treatment, while HAMD-17 and HAMA in observation group were lower than those in control group(P<0.05). After treatment, ET-1, IL-6, TNF-α and vWF decreased in the two groups, while NO increased(P<0.05). After treatment, ET-1 and vWF in the observation group were lower than those in the control group, while NO was higher than that in the control group(P<0.05). After treatment, SNDD, RMSSD, SDANN and PNN50 in the observation group were higher than those before treatment(P<0.05), and all indexes in the control group also showed an increasing trend, but the differences were not statistically significant. After treatment, SNDD and RMSSD in observation group were higher than those in control group(P<0.05). Conclusion CBT combined with SSRI can improve anxiety symptoms, autonomic nerve function and endothelial cell function in CHD patients.