〔Abstract〕 Objective To explore the effect and mechanism of sodium aescinate on liver fibrosis. Methods The liver fibrosis model of rats was induced by CCl4, and the treatment group was treated with sodium aescinate. The collagen and fibrosis degree of rat liver tissue were detected by HE, Masson staining and immunohistochemical staining. The growth and proliferation of HSC-T6 cells were detected by MTT and clone formation. The apoptosis of HSC-T6 cells was detected by flow cytometry, and protein expression in the cells was detected by Western blot. Results Sodium aescinate decreased the production of collagen in the rat liver and reduced fibrosis.Sodium aescinate inhibited the growth and proliferation of HSC-T6 cells, reduced protein expression and increased cell apoptosis. Sodium aescinate inhibited the PI3 K/AKT/mTOR pathway and eIF4 F complex formation of HSC-T6 cells. Conclusion Sodium aescinate can inhibit the synthesis of eIF4 F complex through PI3 K/AKT/mTOR pathway and alleviate the progression of liver fibrosis in rats.