〔Abstract〕 Objective To explore the clinical value of neutrophiletolymphocyte ratio(NLR),monocyte to lymphocyte ratio(MLR) and carcinoembryonic antigen(CEA) in diagnosing gastric cancer. Methods A retrospective analysis was made to the clinical data of 99 cases with gastric malignancy(cancer group) and 101 patients with benign gastric diseases(control group) while the indexes of routine blood tests and CEA detection were analyzed as well; receiver operating characteristic(ROC) curve was applied in evaluating the value of single or combined detection of NLR,MLR and CEA in the diagnosis of gastric cancer so as to find out the best cut-off value. Results The value of MLR and CEA in cancer group were higher than those in the control group, and the difference was statistically significant(P<0.05). The difference of NLR between the cancer group and the control group had no statistical significant(P=0.485). The area of ROC curve(AUC) of MLR,NLR,CEA and the combination of them was 0.668, 0.529, 0.834 and 0.852 respectively; the best cut-off was 0.255, 3.125, 2.31 ng/ml and 4.552 9 respectively; the sensitivity was 50.5%, 23.2%, 72.7% and 56.6%, and the specificity was 84.2%, 95.0%, 77.2% and 98.0% respectively. Conclusion There is a certain correlation between MLR, NLR, CEA and gastric cancer, and the combination of them can promote the diagnostic efficacy of gastric cancer.