〔Abstract〕 Thirty healthy adults New Zealand white rabbit were used and randomly divided into fast decompression group, controlled decompression group, and sham group, with 10 rabbits in each group. After the operation within 24 hours, the behavioral scores from each group was evaluated, and brain water content, nuclear factor-kappa(NDRG2), Caspase-3 expression level and the situation in brain cell apoptosis were also evaluated. Compared with the sham group, zoological score, brain tissue water content, expression of Caspase-3 and apoptosis of brain cells increased in the control decompression group and the fast decompression group, but the expression level of NDRG2 decreased. Compared with the fast decompression group, the animal behavioral score, brain tissue water content, expression of Caspase-3 and degree of brain cell apoptosis decreased in the control decompression group, but the expression level of NDRG2 increased. The controlled decompression technique can reduce the degree of brain edema and inhibit the degree of brain cell apoptosis by increasing the expression of NDRG2, so as to reduce the degree of cerebral ischemia reperfusion injury and improve the prognosis of brain injury.