〔Abstract〕 Objective To provide references for the diagnosis, treatment, prevention and control of the disease by analyzing the clinical characteristics, epidemiological characteristics and prognostic factors of patients infected with novel Bunyavirus. Methods Retrospective analysis was performed on 202 patients infected with novel Bunyavirus. According to the prognosis of the patients, the patients were divided into the survival group(n=164) and the death group(n=38). The general data, clinical manifestations, and laboratory test indicators of patients in the survival group and the death group(within 24 hours) were compared. Multivariate Logistic regression analysis was conducted on the basis of univariate analysis for the two groups of data, and the independent influencing factors of mortality of patients infected with Bunyavirus were obtained. Results Among the 202 confirmed cases, 86 were male and 116 were female, aged 52～73(62.8±10.6) years. The survival group was significantly younger than the death group, and the heat course was significantly longer than that of the survival group(P<0.05). However, there was no statistically significant difference between the two groups in terms of gender, region, occupation, onset distance to visit the doctor, insect bite history, etc. There was no significant difference in clinical symptoms(fever, hyperneckiness, headache, fatigue, insufficiency, nausea, diarrhea, vomiting, cough, muscle aches, shivers, lymph node enlargement, abdominal discomfort, etc.) between the two groups. The proportion of acute pancreatitis, central nervous system damage, bleeding, myocardial damage and arrhythmia in the death group was significantly higher than that in the survival group(P<0.01).In the death group, viral load, ferritin, lactic lehydrogenase(LDH) and other indicators were significantly higher than those in the survival group, while lymphocyte count, platelet count, Th cell count and IgM positive rate were all lower than those in the survival group(P<0.01). Among them, thermal course, age, lymphocyte count and active partial thromboplastin time(APTT) were independent influencing factors of death. Conclusion The older the age, the longer the heat course, the longer the APTT and the lower the lymphocyte count, the worse the prognosis of the patients infected with the novel Bunyavirus.