〔Abstract〕 Objective To investigate the effects of renal denervation(RDN) on ventricular arrhythmia after acute myocardial infarction(AMI) and its mechanism. Methods Using a rat myocardial infarction model, 24 Sprague-Dawley(SD) rats were divided into four groups: the control group(Control), the AMI group, the RDN-1 d+AMI group and the RDN-2 w+AMI group. The SD rats were subjected to RDN intervention, and the AMI model was established after feeding for different times. PowerLab multi-channel ECG monitor was continuously recorded after surgery to monitor the inhibitory effect of RDN on the occurrence of ventricular arrhythmia. After 1 h of observation,the heart tissue was collected,and TH staining was used to detect cardiac sympathetic nerve activity. Western blot was used to detect the expression of various ion channel proteins in the myocardial infarction area. Renal sympathetic nerve activity was detected by Power Lab/8 SP biological information acquisition instrument. Results Compared with the AMI group,the frequency of ventricular tachycardia in the RDN-1 d + AMI group and RDN-2 w +AMI group reduced,the difference was statistically significant( P<0. 01),and the decrease in the RDN-1 d group was more obvious. Compared with the sympathetic nerve discharge in the Control group,the RDN-1 d group and the RDN-2 w group decreased,the difference was statistically significant( P<0. 01),and the RDN-1 d group was more effective. TH staining suggested that RDN could inhibit local sympathetic nerve activity after AMI. Compared with the control group,the protein expressions of Nav1. 5,Cav1. 2 and Kir2. 1 in the AMI group were down-regulated,while compared with the AMI group,the RDN-2 w + AMI group could inhibit the down-regulation of Nav1. 5,Cav1. 2 and Kir2. 1 protein expression,while the RDN-1 d + AMI group could not inhibit the down-regulation of protein expression. Conclusion RDN can effectively reduce the occurrence of ventricular arrhythmias after AMI.In the early stage,it mainly inhibits renal sympathetic nerve discharge,and later inhibits renal sympathetic discharge and ion channel protein upregulation.