〔Abstract〕 Objective To explore the pharmacological mechanism of Qishen Yiqi dropping pills in the treatment of myocardial infarction(MI) by network pharmacology. Methods The Chinese medicine system pharmacology database and analysis platform(TCMSP) was used to search for all active compound components and targets of the four herbs in the Chinese herbal compound of Qishen Yiqi dropping pills. The targets of myocardial infarction were collected by OMIM, TTD, PharmGKB, DisGinNET and DrugBank databases. Then disease targets were merged with the therapeutic targets of the drug to obtain the targets of the drug for the disease. The drug components-disease targets network was constructed by Cytoscape software, and the core targets of the drug for treating myocardial infarction were filtrated by analyzing the network. The DAVID database performed KEGG enrichment analysis, and the Omicshare database performed GO secondary classification enrichment and visualized the results of KEGG enrichment. Results Oral bioavailability(OB)≥30%, drug-likeness(DL)≥0.18, Caco-2 permeability(Caco-2)≥-0.4 and half-life(HL)≥4 h were chosen as the active compounds ADME screening conditions. A total of 82 active components and 610 component targets were obtained. Five disease databases were used to search for myocardial infarction targets and a total of 1 713 related targets were obtained. Then 103 targets were mapped to the drug targets successfully. DAVID enrichment analysis was performed on 27 core targets greater than the average degree, and ADRB2, CHRM3, CHRM2, NOS3, NOS2, ADRA1 D, CALM1, PIK3 CG, DRD1, PDE3 A, F2, GSK3 B, COX2, ESR2, ACHE, SCN5 A, COX1, PTGS2,18 genes were the core targets for myocardial infarction, which were enriched in 19 pathways related to myocardial infarction, such as calcium signaling pathway, cAMP signaling pathway, and cGMP-PKG signaling pathway. Conclusion The theory and method of systemic pharmacology confirm the multi-components, multi-targets and multi-pathways treatment characteristics of Qishen Yiqi dropping pills, and predict its possible mechanism for treating MI, which provide reference and theory for the basic research of the disease simultaneously.