〔Abstract〕 Objective To investigate the changes and mechanisms of attention function lateralization in Parkinson's disease(PD). Methods The lateralized attention network test was used to compare the orientation, alertness and executive function of both cerebral hemispheres of 32 PD patients and 28 health controls(HCs) by calculating the mean response time(RT) and error rate(ERR). Results In the orientation network, the RT of the right field of vision of the HCs group was longer than that of the left, showing a statistically significant difference(t=4.751,P<0.000 1), while the RT of the left field of vision(67.63±43.59) ms of PD was longer than that of the right(32.02±52.99) ms, showing a statistically significant difference(t=2.923,P=0.006 3). In the alertness network, there was no significant difference in RT between the left and right visual fields in the HCs group, and the left visual field RT in PD group was negative, no alertness effect was observed. In the executive network, there was no significant difference in RT between the left and right field of HCs and PD. There was no significant difference in ERR between the two groups in the three networks. Conclusion The orientation function of PD patients showed the dominance of the right cerebral hemisphere, while the HCs showed the dominance of the left cerebral hemisphere, and the right cerebral alertness was impaired in the PD group, suggesting that the change of the dominant cerebral hemisphere of the attention function of PD patients might be related to the abnormal secretion of neurotransmitters in the left and right cerebral hemispheres.