〔Abstract〕 Objective To compare clinical effects of mini-stimulation and luteal phase ovulation-inducing programs in patients with failurein vitrofertilization/intracytoplasmic sperm injection(IVF/ICSI). Methods The clinical data of infertile patients with a history of IVF/ICSI failure who received IVF/ICSI treatment at our reproductive center were retrospectively analyzed. They were divided into two groups according to the different stimulation protocols: luteal phase ovulation inducting protocol(98 cases), mini-stimulation protocol(551 cases). The differences in baseline data, ovulation-inducing situation and pregnancy outcome between the two groups were compared. Results There was no significant difference in age, duration of infertility, body mass index(BMI), the basic level of follicle stimulating hormone(FSH), proportion of primary infertility, and proportion of IVF between the two groups(P>0.05); There was also no significant difference in the duration of Gn, the number of retrieved oocytes, MII oocytes, 2 PN zygotes, transferable embryos, and transferred embryos between the two groups(P>0.05). But the total Gn dosage in the luteal phase ovulation-inducing group was significantly higher than that in the mini-stimulation group, and the difference was statistically significant(P<0.05). There was no significant difference in fertilization rate, cycle cancellation rate, implantation rate, and clinical pregnancy rate between the two groups(P>0.05). Conclusion The luteal phase ovulation-inducing and mini-stimulation protocols have similar therapeutic effects in patients with a history of IVF/ICSI failure.