〔Abstract〕 Objective To analyze epidemiology of carbapenem-resistantKlebsiella pnuemoniae(CRKP) among different clones. Methods The phylogenetic relationship was analyzed by multilocus sequence typing(MLST) and the resistant genes were detected by polymerase chain reaction. What′s more, the retrospective analysis was conducted to analyze clinical characteristic of infected patients. Results 13 sequence types(STs) were detected in this study. And ST11 CRKP-infected stains(n=44) were more likely to produceKlebsiella pnuemoniaecarbapenemase(KPC)(P<0.001) compared with non-ST11 ones(n=16), which had higher resistant rate to aminoglycsides(P=0.014). The results of univariate analysis showed that exposure to cephalosporins(P=0.049) and have combined bacteria(P=0.020) prior to infection had close correlations with infection due to ST11 CRKP, but the results of multivariate analysis showed there was no statistical significance. Conclusion Compared with non-ST11-infected strains, ST11 CRKP strains are associated with the production of KPC, but there are no differences in background characteristics and outcomes between groups.