Found programs:
Authors:Xu Wenjuan; Zhu Xiaoqian; Wang Jianye; Zhou Ping
Keywords:benign ovarian tumors;ovarian reserve;assisted reproductive therapy;clinical outcomes
DOI:10.19405/j.cnki.issn1000-1492.2022.10.030
〔Abstract〕 Objective To explore the effects of surgical treatment for benign ovarian tumors on reproductive outcomes. Methods One hundred and twenty-six patients(case group) who underwentin vitrofertilization and intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET) and a history of benign ovarian tumor surgery were retrospectively analyzed. Totally one hundred and forty patients who underwent IVF/ICSI-ET due to female tube factors during the same period were matched as control group. The general characteristics, the first controlled ovarian hyperstimulation(COH) process, clinical outcomes and cumulative reproductive outcomes were then compared. Results There was no significant difference in the general characteristics, total dosage of gonadotropin(Gn) used, duration of Gn used, estrogen(E2) level and intima thickness on human chorionic gonadotropin(HCG) injection day during the first COH period between the two groups(P>0.05). There was no significant difference in the number of oocytes retrieved, number of MII, follicle-oocyte index(FOI) and ovarian sensitivity index(OSI)(P>0.05). However, the number of transferable embryos and high-quality embryos in control group was significantly higher than that in case group(P<0.05), while the transferred embryo number, implantation rate and clinical pregnancy rate were not statistically significant(P>0.05). Moreover, the cumulative pregnancy rate and live birth rate, clinical pregnancy rate and live birth rate per transplant cycle, the number of oocytes retrieval cycles required per live birth, the number of transplant cycles required per live birth, and the number of embryos required per live birth were also not statistically significant between the two groups(P>0.05). Conclusion Compared with control group, the clinical outcomes of assisted reproductive therapy in benign ovarian tumors infertility patients with normal ovarian reserve after surgical treatment are not significantly different.